Patrice Koehl
Department of Computer Science
Genome Center
Room 4319, Genome Center, GBSF
451 East Health Sciences Drive
University of California
Davis, CA 95616
Phone: (530) 754 5121

Computational Structural Biology: Winter 2024

Ab Initio Protein Structure Prediction

AlphaFold is an AI system developed by DeepMind (London, UK) that predicts a protein’s 3D structure from its amino acid sequence. It regularly achieves accuracy competitive with experiment. In this chapter, we introduce the concept of ab initio protein structure prediction, describe qualitatively how AlphaFold works, and illustrate its successes and its limitations.

ALphaFold: successes

Lecture Notes

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Further Reading

  Page last modified 19 February 2024