Patrice Koehl
Department of Computer Science
Genome Center
Room 4319, Genome Center, GBSF
451 East Health Sciences Drive
University of California
Davis, CA 95616
Phone: (530) 754 5121
koehl@cs.ucdavis.edu




Computational Structural Biology: Winter 2026


Fluctuations in Biology


"If we were to name the most powerful assumption of all,
which leads one on and on in an attempt to understand life,
it is that all things are made of atoms,
and that everything that living things do can be understood in terms of the
jigglings and wigglings of atoms."
Richard Feynman


Fluctuations are at the core of all biological systems in action. Compared to man-made machines, which work deterministically, biological systems fluctuate at various levels and scales, from the individual molecules to cells as a whole. Fluctuations at the molecular level for example are the result of temperature, that translates into thermal energy. They are not merely imperfections in the biological machines; rather, they are often key elements in their working mechanisms. Many living organisms have in fact evolved to optimally utilize these fluctuations. Understanding how biology utilizes fluctuations should lead to further insights into the design, function, and regulation of biologica systems.



(from 2003 review paper by Lenksi (see below))



Lecture Notes


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Further Reading









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